Yes. I've attached a screenshot showing what the title screen looks like in Windowed mode with Windows' text and icon size setting at 150 percent, a screen resolution of 1,600 by 1,200, and Telepath Tactics' minimum info box font size. You'll notice that the text box in the lower left corner and the right side of the window are cut off.
I don't know if there's a way around this problem, and Windows does warn you when you use a larger text and icon size that programs may not fit on screen.
I don't know if there's a way around this problem, and Windows does warn you when you use a larger text and icon size that programs may not fit on screen.